Is There a Relationship of Cortisol and Sex Steroid Hormones With Mental Health in Middle-Aged Adults? The FIT-AGEING Study
Authors' conclusion
In summary, these results suggest that the increased levels of steroid hormones-within the normal values-are associated with better mental health in middle-aged adults.
Study context
- Population
- Apparently healthy middle-aged adults aged 45 to 65 years (women, 53%), FIT-AGEING study
- Participants
- 73 adults
- Outcome
- Association of plasma cortisol, testosterone, free testosterone, SHBG and DHEAS with mental health (BDI-II depression severity, health-related quality of life, hope, life satisfaction, optimism-pessimism)
Main finding
As reported in the abstract
Association of steroid hormones with mental health
- Men: testosterone and free testosterone inversely associated with Beck Depression Inventory-II (BDI-II)
- all P ≤ .042
- Women: cortisol positively related with Satisfaction with Life Scale scores
- all P ≤ .045
- Women: testosterone, free testosterone, sex hormone-binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEAS) negatively correlated with BDI-II
- all P ≤ .045
Observational data: associations, not effects.
Original publication
Is There a Relationship of Cortisol and Sex Steroid Hormones With Mental Health in Middle-Aged Adults? The FIT-AGEING Study. Endocr Pract. Published 19 July 2024. doi:10.
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