Effects of Physical Activity on Blood Lipids and Hemoglobin A1c in Healthy Pregnant Women: The FitMum Randomized Controlled Trial

Endocr PractPublished Secondary analysis of the FitMum randomised controlled trial

Authors' conclusion

Whilst there were no effects of offering PA interventions, higher PA was associated with reduced increases in TC, HDL-C, and LDL-C as pregnancy progressed.

Study context

Population
Healthy pregnant women included before week 15 + 0
Participants
216 women
Comparison
Two physical activity (PA) interventions throughout pregnancy vs standard care
Primary endpoint
Maternal blood lipid (TC, HDL-C, LDL-C, TG) and HbA1c concentrations
Follow-up
Week ≤15 + 0, 28+0-6, 34+0-6, and at delivery

Primary result

As reported in the abstract

Maternal lipids and HbA1c · during pregnancy
  • No effects of the PA interventions on maternal lipids or hemoglobin A1c (HbA1c)
  • Linear mixed effects models

Further findings

PA per se (activity tracker): min/week of moderate-to-vigorous PA and increase in lipids as pregnancy progresses

Less increase in total cholesterol (TC)
−1.3E-04, P = .020
Less increase in low-density lipoprotein cholesterol (LDL-C)
−8.5E-05, P = .035
  • Linear regression

PA per se (activity tracker): active kilocalories and increase in lipids as pregnancy progresses

Less increase in TC
−5.5E-05, P < .001
Less increase in high-density lipoprotein cholesterol (HDL-C)
−9.5E-06, P = .024
Less increase in LDL-C
−3.2E-05, P = .005
  • Linear regression

Original publication

Effects of Physical Activity on Blood Lipids and Hemoglobin A1c in Healthy Pregnant Women: The FitMum Randomized Controlled Trial. Endocr Pract. Published 9 July 2024. doi:10.1016/j.eprac.2024.07.002

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