Iodine uptake variability as a predictive biomarker for radioiodine therapy outcomes in Graves Disease: Validation through multi‐time‐point RAIU assessment in a 1249‐patient cohort
Authors' conclusion
In this study, we proposed and defined IUV as a predictive biomarker for GD, and verified its impact on the prognosis of GD treated with RAI. Low IUV was associated with a poor clinical prognosis.
Study context
- Population
- Patients with Graves Disease (GD) who underwent RAI therapy at the Second Affiliated Hospital of Anhui Medical University, October 2012–October 2022333 males · 916 females
- Participants
- 1,249 patients
- Exposure
- Success vs Failure
- Successn = 1,014
- Failuren = 235reference
- Outcome
- Success rate of RAI therapy for GD
- Follow-up
- Within 36 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
RAI therapy outcome · 3-year follow-up
- RAIU-Range/Max recommended as representative IUV indicator; clinical threshold
- 28.8%
Observational data: associations, not effects.
Original publication
Iodine uptake variability as a predictive biomarker for radioiodine therapy outcomes in Graves Disease: Validation through multi‐time‐point RAIU assessment in a 1249‐patient cohort. Diabetes Obes Metab. Published 4 August 2025. doi:10.
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