Investigating the Spectrum of Normoglycemia: Time in Glycemic Ranges and Their Association With Metabolic Outcomes in Individuals Without Diabetes
Authors' conclusion
We provide population references for time spent in different glycemic ranges by adults without diabetes. Although our study is observational and not designed to establish causality, our findings suggest that even within normoglycemic ranges, less time at <140 mg/dL is associated with unfavorable health parameters and higher incident metabolic disease risk.
Study context
- Population
- Adults without diabetes aged 40–70 years (54% women), Human Phenotype Project, with CGM (FreeStyle Libre Pro)
- Participants
- 8,687 adults
- Outcome
- Distribution of time in tight and broader glycemic ranges; associations with metabolic health and incident metabolic disease
- Follow-up
- 2.6 ± 1.3 years
Methodological detailscross-sectional and longitudinal analyses
- Cross-sectional and longitudinal analyses
Main finding
As reported in the abstract
Time within 70-140 mg/dL, median (IQR 91.8-98.2)
93.0%
Time within 70-180 mg/dL, median (IQR 95.1-99.8)
95.2%
Time below 140 mg/dL (IQR 97.6-97.8)
97.7%
Time below 180 mg/dL (IQR 99.9-99.9)
99.9%
Observational data: associations, not effects.
Further findings
Incident metabolic disease · 2.6 ± 1.3 years
- Less time at <180 mg/dL, HR
- 1.21 (95% CI 1.15-1.26)
- Less time at <140 mg/dL, HR
- 1.34 (95% CI 1.26-1.42)
Cross-sectional correlations with clinical phenotypes
- Less time at <140 mg/dL correlated with higher waist circumference, visceral fat, TG, blood pressure, serum ALT and liver attenuation, and lower HDL-C and mean nocturnal oxygen saturation; associations weakened with <180 mg/dL threshold
- Age- and sex-adjusted
Original publication
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