Gestational diabetes & diabetes in pregnancy
Intrapartum and Early Postpartum Use of Automated Insulin Delivery in Type 1 Diabetes: A Prespecified Analysis of the CIRCUIT Randomized Controlled Trial
Primary result · % time in range 63-140 mg/dLResult — go to the resultMean adjusted difference 13.2 percentage points 95% CI 5.2–21.2Authors' conclusion
Use of this closed-loop system resulted in superior intrapartum and early postpartum glycemia compared with standard care without safety concerns.
Study context
- Population
- Pregnant women with T1D, intrapartum and early postpartum
- Comparison
- Control-IQ closed loop vs standard care
- Closed loopn = 44
- Primary endpoint
- % time in pregnancy-specific glucose range (63-140 mg/dL) by CGM
- Follow-up
- 24 h prior to childbirth
Methodological detailsprespecified analysis
- Prespecified analysis
Primary result
% time in range 63-140 mg/dL · 24 h before delivery
Mean adjusted difference
13.2 percentage points
95% CI 5.2–21.2
By group
Closed loopvs Standard care
mean adjusted difference 13.2 percentage points (95% CI 5.2–21.2)
As reported in the abstract
Secondary outcomes
Key secondary: % time <70 mg/dL · first postpartum week
mean adjusted difference (percentage points) −1.8 (−0.9 to −2.7)
Intrapartum IV insulin use
P < 0.001
- Continued closed loop intrapartum · 24 h before delivery
- 89% · 39 of 44
Safety
Intrapartum intravenous insulin use
P < 0.001
| Outcome | Closed loop | Standard care |
|---|---|---|
| Maternal severe hypoglycemia · postpartum | — not stated in the abstract | one episode events |
— not stated in the abstract
Maternal severe hypoglycemia · postpartum
- No maternal severe hypoglycemia occurred in the closed-loop group
Diabetic ketoacidosis
- No diabetic ketoacidosis occurred in either group
Original publication
Intrapartum and Early Postpartum Use of Automated Insulin Delivery in Type 1 Diabetes: A Prespecified Analysis of the CIRCUIT Randomized Controlled Trial. Diabetes Care. Published 27 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →