Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation
Authors' conclusion
This was the first study to compare the effects of exercise on IMCL and EMCL use in males with CO and AO. The decreases in IMCL of the AO group is similar with those observed in the literature in lean individuals. We made the novel observation that with moderate intensity cycling, males with CO do not appear to use IMCL as effectively as those with AO, suggesting perturbations in IMCL metabolism.
Study context
- Population
- Males with childhood-onset or adulthood-onset obesity; standardized meals for 3 days before exercise visit
- Participants
- 5 vs 5
- Comparison
- Childhood-onset obesity vs adulthood-onset obesity
- COn = 5
- AOn = 5reference
- Outcome
- Use of intramyocellular (IMCL) and extramyocellular (EMCL) lipids measured by magnetic resonance spectroscopy (MRS) in response to 90 minutes of moderate intensity cycling
- Follow-up
- Before and after exercise
Methodological detailsBody composition by DEXA; energy expenditure and substrate oxidation by indirect calorimetry
- Body composition by DEXA; energy expenditure and substrate oxidation by indirect calorimetry
Main finding
As reported in the abstract
post-exercise
- Decrease in intramyocellular (IMCL) post-exercise in AO, not demonstrated in CO
- No changes in extramyocellular (EMCL) post-exercise in either group
Further findings
Substrate oxidation at rest and during exercise
- Not different between groups
Original publication
Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation. Int J Obes (Lond). Published 29 January 2025. doi:10.
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