Association of BCHE gene SNP rs1803274 (K-variant) and rs3495 with obesity in Pakistani population group
Authors' conclusion
In conclusion, the study suggests that BChE and inflammatory cytokines play a significant role in the development and pathogenesis of obesity and can also act as good diagnostic biomarkers for obesity and its related metabolic disorders.
Study context
- Population
- Pakistani population; people with obesity and volunteers without obesity
- Participants
- 350 vs 200
- Comparison
- People with obesity vs volunteers without obesity
- Obesityn = 350
- No obesityn = 200reference
- Outcome
- Association of BCHE gene SNPs rs1803274 (K-variant) and rs3495 with obesity risk; serum BChE and inflammatory markers
Main finding
As reported in the abstract
Association of BCHE SNPs with obesity risk
Odds ratio (CI)P value
rs1803274 (K-variant)
2.01(1.21–3.33)
P = 0.0063rs3495
1.80(1.09–2.96)
Observational data: associations, not effects.
Further findings
Clinical parameters
- Higher blood pressure and LDL, lower HDL in obesity vs no obesity
- Logistic regression: obesity related to higher BChE activity, blood pressure, LDL and lower HDL
Original publication
Association of BCHE gene SNP rs1803274 (K-variant) and rs3495 with obesity in Pakistani population group. Int J Obes (Lond). Published 28 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →