Intra‐pancreatic fat is associated with continuous glucose monitoring metrics
Authors' conclusion
Increased fat in the pancreas is associated with excessive glycaemic variability. Fatty change of the pancreas may contribute to heightening the risk of cardiovascular diseases.
Study context
- Population
- Individuals with abdominal MRI (3.0 Tesla) quantification of pancreatic fat and 7-day CGM (Dexcom G6)
- Participants
- 38 individuals
- Exposure
- Fatty change of the pancreas vs normal pancreas; Intra-pancreatic fat deposition (IPFD) as continuous variable
- Outcome
- Relationship of fat in the pancreas with time spent in different glycaemic ranges (TAR, TIR, TBR)
- Follow-up
- 7-day CGM period
Main finding
As reported in the abstract
CGM metrics (TAR, TIR) by pancreatic fat, adjusted for covariates
- IPFD associated with time above range (TAR) (p = .036); 0.3 unit increase in TAR per 1% increase in IPFD
- IPFD associated with time in range (TIR), decrease in TIR with increasing IPFD (p = .042)
- Fatty change of the pancreas vs Normal pancreas: P = 0.034
- Fatty change of the pancreas vs Normal pancreas: P = 0.047
- Adjusted for age, sex, body composition and other covariates
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| TBRNot associated · adjusted for covariates | P = 0.555 |
TBR
- IPFD not associated with TBR (p = .805)
Original publication
Intra‐pancreatic fat is associated with continuous glucose monitoring metrics. Diabetes Obes Metab. Published 26 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →