Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes: A subgroup analysis from the FLASH‐UK study
Authors' conclusion
Intermittently scanned continuous glucose monitoring is generally effective across a range of baseline characteristics.
Study context
- Population
- Adults with T1D and HbA1c ≥58 mmol/mol (≥7.5%); females 44%, mean (SD) baseline HbA1c 71 (9) mmol/mol, age 44 (15)randomised 1:1
- Participants
- 156 adults
- Comparison
- Intermittently scanned continuous glucose monitoring (isCGM) vs self monitoring of blood glucose (SMBG)
- isCGMn = 78
- SMBGn = 78reference
- Primary endpoint
- HbA1c (primary outcome), pre-specified subgroup analysis
- Follow-up
- 24 weeks
Methodological detailspre-specified subgroup analysis, multicentre, parallel-design
- Pre-specified subgroup analysis
- Multicentre
- Parallel-design
Primary result
As reported in the abstract
HbA1c treatment effect by subgroup
Larger HbA1c between-group difference in younger people: reduction per additional 15 years of age (mmol/mol)
2.7
95% CI 0.3–5.0; p = 0.028
Secondary outcomes
Mean, %
| Outcome | isCGM | SMBG | Adjusted mean difference (%) (95% CI) | P value | |
|---|---|---|---|---|---|
| HbA1c, overall · 24 weeks | 7.9 (SD 0.8) | 8.3 (SD 0.9) | −0.5 (−0.7 to −0.3) | P < 0.001 | |
| −1−0.500.5Difference, % (linear scale) |
HbA1c at baseline
TIR (% 3.9-10 mmol/L) and TBR (% <3.9 mmol/L) by subgroup
- TIR difference larger for those with at least a bachelor's degree
- TBR difference larger for those using injections, older people and those with less than bachelor's degree
Original publication
Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes: A subgroup analysis from the FLASH‐UK study. Diabet Med. Published 5 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →