Interacting and joint effects of triglyceride-glucose index (TyG) and body mass index on stroke risk and the mediating role of TyG in middle-aged and older Chinese adults: a nationwide prospective cohort study
Main finding · Incident strokeResult — go to the resultHazard ratio 2.05 95% CI 1.37–3.06Authors' conclusion
TyG appeared to be associated with stroke risk and mediates more than 50% of the total association between BMI and stroke in middle-aged and older Chinese adults. Public health efforts aiming at the reduction of body weight might decrease the stroke risk due to insulin resistance and the burden of stroke.
Study context
- Population
- Middle-aged and older Chinese adults without stroke history at baseline, China Health and Retirement Longitudinal Study (from 2011); 46.3% men, mean age 59.23 years
- Participants
- 8,231 participants
- Exposure
- Body mass index (BMI) and TyG categories and their joint and interacting effects on stroke
- Outcome
- Stroke incidence, as determined through self-reports
- Follow-up
- June 1, 2011, to June 30, 2018
Methodological detailsnationwide, nationally representative, mediation analysis
- Nationwide
- Nationally representative
- Mediation analysis
Main finding
Incident stroke · median follow-up 7.1 years
Hazard ratio
2.05
95% CI 1.37–3.06
BMI ≥ 28.0 kg/m² + TyG Q4vs BMI < 24.0 kg/m² + TyG Q1
HR 2.05 (95% CI 1.37–3.06)
As reported in the abstract
- Developed stroke (all participants)
- 585 (7.1%)
- Proportion of BMI–stroke association mediated by TyG, BMI 24.0-27.9 kg/m²
- 16.3%
- Proportion of BMI–stroke association mediated by TyG, BMI ≥ 28.0 kg/m²
- 53.8%
- No significant additive interaction BMI × TyG: RERI
- 1.78 (95% CI - 1.29-4.86)
- No significant multiplicative interaction BMI × TyG: HR
- 1.40 (95% CI 0.86-2.27)
Observational data: associations, not effects.
Further findings
Predictive performance for stroke (AUC)
- AUC BMI+TyG
- 0.602
- AUC BMI
- 0.581
- AUC TyG
- 0.583
- Combining BMI and TyG enhanced predictive performance
Original publication
Interacting and joint effects of triglyceride-glucose index (TyG) and body mass index on stroke risk and the mediating role of TyG in middle-aged and older Chinese adults: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 13 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →