Inter-individual variation in gastric emptying is related to GLP-1 response to intraduodenal glucose exposure in health
Authors' conclusion
In healthy individuals, gastric emptying of a glucose drink is related to the magnitude of the GLP-1 response to intestinal glucose exposure.
Study context
- Population
- Healthy participants (20F/22 M, age: 35.1 ± 2.1 years; BMI 24.5 ± 0.6 kg/m²)
- Participants
- 42 participants
- Outcome
- Relationship between gastric half-emptying time (T50) of oral glucose and GLP-1 iAUC response to intraduodenal glucose
Main finding
As reported in the abstract
T50 of oral glucose vs GLP-1 iAUC (t = 0-120 min) in response to intraduodenal glucose
- Direct relationship between T50 and GLP-1 incremental area under the curve (iAUC), r
- 0.33
- P
- P = 0.03
Further findings
| Outcome | P value |
|---|---|
| GLP-1 iAUC0-120min to intraduodenal glucose by T50 tertile · 0-120 minSlower gastric emptying vs Faster gastric emptying · GLP-1 iAUC greater with slower gastric emptying | P = 0.02 |
Original publication
Inter-individual variation in gastric emptying is related to GLP-1 response to intraduodenal glucose exposure in health. J Clin Endocrinol Metab. Published 14 July 2026. doi:10.
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