Insulin independence following islet transplantation improves long‐term metabolic outcomes
Authors' conclusion
This is the largest UK single-centre study on islet transplant to date. Our findings demonstrate significantly improved outcomes in patients who achieved insulin independence following islet transplantation.
Study context
- Population
- Patients with T1D who underwent islet transplantation in Scotland up to 31 January 2020; 74.5% had >50 severe hypoglycaemic episodes in the year before transplant
- Participants
- 60 patients
- Exposure
- Insulin independence at any point after islet transplantation vs no insulin independence
- Outcome
- Graft survival (stimulated C-peptide >50 pmol/L)
Methodological detailsdata collected prospectively, single-centre
- Data collected prospectively
- Single-centre
Main finding
As reported in the abstract
Mean graft survival time
Observational data: associations, not effects.
Secondary outcomes
Insulin requirement and insulin independence after transplant (all patients)
- Decrease in insulin requirement following transplant
- 55.0%
- Achieved insulin independence
- 30.0%
Graft function, glycaemic control and hypoglycaemic awareness · 1 year
- Insulin independence associated with significantly improved graft function, glycaemic control and hypoglycaemic awareness
Original publication
Insulin independence following islet transplantation improves long‐term metabolic outcomes. Diabet Med. Published 15 November 2023. doi:10.
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