Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans
Authors' conclusion
BMI and insulin both causally decreased serum sOb-R levels. Conversely, intensive exercise and food intake acutely increased sOb-R. Our results suggest that sOb-R is involved in short-term regulation of leptin signaling, either directly or indirectly, and that hyperinsulinemia may reduce leptin signaling.
Study context
- Population
- Humans in 5 independent clinical studies (n = 24–823); sOb-R quantified in serum or plasma by ELISA5 studies, n = 24–823
- Outcome
- Serum soluble leptin receptor (sOb-R) levels in relation to glucose, insulin, body fat, BMI, food intake and physical activity
Methodological detailscross-sectional, interventional and Mendelian randomization designs, 5 independent clinical studies, mixed-model regression, 2-sample Mendelian randomization
- Cross-sectional, interventional and Mendelian randomization designs
- 5 independent clinical studies
- Mixed-model regression
- 2-sample Mendelian randomization
Main finding
As reported in the abstract
Determinants of serum sOb-R (β, 95% CI)
- Cross-sectional (pooled): Body mass index (BMI), inverse association
- −0.19 [−0.21 to −0.17]
- Cross-sectional (pooled): body fat, inverse association
- −0.12 [−0.14 to −0.10
- Cross-sectional (pooled): fasting C-peptide, inverse association
- −2.04 [−2.46 to −1.62]
- Acute hyperinsulinemia during euglycemic glucose clamp, decrease (first of 2 independent studies)
- −0.5 [−0.7 to −0.4]
- Acute hyperinsulinemia during euglycemic glucose clamp, decrease (second of 2 independent studies)
- −0.5 [−0.6 to −0.3]
- Intensive exercise, immediate increase
- 0.18 [0.04 to 0.31]
- Food intake, immediate increase
- 0.20 [0.06 to 0.34]
- 2-sample Mendelian randomization, higher fasting insulin → lower sOb-R (inverse variance weighted)
- −1.72 [−2.86 to −0.58]
- 2-sample Mendelian randomization, higher BMI → lower sOb-R (inverse variance weighted)
- −0.20 [−0.36 to −0.04]
Observational data: associations, not effects.
Original publication
Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans. J Clin Endocrinol Metab. Published 2 December 2022. doi:10.
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