Inhibin B and Anti-Müllerian Hormone (AMH) for Diagnosis of Hypogonadotropic Hypogonadism in Boys Under 1 Year of Age: A Case-control Study
Authors' conclusion
Inhibin B and/or AMH can be used to diagnose CHH in boys < 1 year of age.
Study context
- Population
- Infant boys aged 0 to 12 months with micropenis and/or cryptorchidism, 7 University Hospitals in France; 4 periods: 1–4 days, 15–65 days (early mini-puberty), 66–179 days (late mini-puberty), 180–365 days (post mini-puberty)
- Participants
- 138 participants
- Comparison
- Inhibin B (INHB), AMH, T, LH and FSH in isolated CHH (iCHH) and combined pituitary hormone deficiency (CPHD) vs idiopathic controls
- iCHHn = 58
- CPHDn = 32
- Controlsn = 48reference
- Outcome
- Discriminating cutoffs of INHB, AMH, T, LH and FSH for CHH diagnosis based on sensitivity and specificity
Methodological detailscase-control, multicenter
- Case-control
- Multicenter
Performance
As reported in the abstract
Diagnostic performance for CHH out of mini-puberty
- INHB at 1 to 4 days, cutoff 150 pg/mL: Sensitivity (Se)/specificity (Sp)
- 100%/75%
- INHB at 1 to 4 days, cutoff 85 pg/mL: Se/Sp
- 89%/100%
- INHB after 180 days, cutoff 100 pg/mL: Se/Sp
- 100%/100%
- AMH after 180 days, cutoff 600 pmol/L: Se/Sp
- 100%/92%
- AMH after 180 days, cutoff 370 pmol/L: Se/Sp
- 75%/100%
- INHB and/or AMH AUC across all 4 periods
- ≥ 0.95
Original publication
Inhibin B and AMH for Diagnosis of Hypogonadotropic Hypogonadism in Boys Under 1 Year of Age: A Case-control Study. J Clin Endocrinol Metab. Published 7 April 2025. doi:10.
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