Inhaled Technosphere Insulin Plus Insulin Degludec for Adults with Type 1 Diabetes: The INHALE-3 Extension Study
Authors' conclusion
HbA1c levels were sustained over 30 weeks using a TI-degludec regimen after switching from AID or MDI.
Study context
- Population
- Adults with T1D switching from usual care (predominantly automated insulin delivery (AID) or MDI); prestudy 44% AID, 9% sensor-augmented pump without automation, 47% MDI45 continued into extension
- Participants
- 123 adults
- Comparison
- Technosphere insulin (TI) plus degludec over 30 weeks
- TI-degludecn = 62
Methodological detailsmulticenter, single-group extension, no scheduled visits before final visit at 30 weeks, 58 of 62 completed the 17-week visit; 45 continued into the extension phase
- Multicenter
- Single-group extension
- No scheduled visits before final visit at 30 weeks
- 58 of 62 completed the 17-week visit; 45 continued into the extension phase
Primary result
As reported in the abstract
HbA1c · 30 weeks
Mean HbA1c at baseline
7.6% ± 1.0%
Mean HbA1c at 17 weeks
7.6% ± 1.0%
Mean HbA1c at 30 weeks
7.4% ± 1.0%
Mean HbA1c change from 17 to 30 weeks
−0.21%
95% CI −0.33% to −0.09%P < 0.001
Further findings
Mean HbA1c over time · baseline, 17 weeks, 30 weeks
- Baseline
- 7.6% ± 1.0%
- 17 weeks
- 7.6% ± 1.0%
- 30 weeks
- 7.4% ± 1.0%
HbA1c <7.0% · baseline, 17 weeks, 30 weeks
- Baseline
- 21%
- 17 weeks
- 30%
- 30 weeks
- 42%
TIR 70-180 mg/dL · baseline, 17 weeks, 30 weeks
- Baseline
- 52% ± 18%
- 17 weeks
- 53% ± 20%
- 30 weeks
- 54% ± 20%
- Mean ± SD
Total daily insulin dose
- Mean total daily TI dose at 30 weeks
- 53 ± 31 U/day
- Total daily rapid-acting insulin analog dose at baseline
- 24 ± 12 U/day
- TI dose about twice baseline rapid-acting analog dose
Safety
Time <54 mg/dL · baseline, 17 weeks, 30 weeks
- Baseline
- 0.4% ± 0.6%
- 17 weeks
- 0.4% ± 0.8%
- 30 weeks
- 0.6% ± 1.0%
- Mean ± SD
Original publication
Inhaled Technosphere Insulin Plus Insulin Degludec for Adults with Type 1 Diabetes: The INHALE-3 Extension Study. Diabetes Technol Ther. Published 1 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →