Inflammation of adenohypophysis is commonly associated with headache in surgically managed Rathke’s cleft cysts
Authors' conclusion
Headache but not pituitary dysfunction was associated with adenohypophyseal inflammation. A trend of increasing headache prevalence was seen with increasing degree of inflammatory infiltrate within RCC.
Study context
- Population
- Patients with surgically managed Rathke's cleft cysts (RCC), April 2016–April 2024; median age 43 years (IQR 32–63), 77% female
- Participants
- 31 patients
- Exposure
- Adenohypophysitis vs no adenohypophysitis in surgically managed RCC
- Adenohypophysitisn = 12
- Outcome
- Headache
- Follow-up
- Preoperative
Methodological detailsindependent histopathology and radiology review
- Independent histopathology and radiology review
Main finding
As reported in the abstract
P = 0.020
- Headache present in all cases with chronic adenohypophyseal inflammation
- 11 cases
Observational data: associations, not effects.
Further findings
Inflammation of RCC (epithelium n = 13, cyst wall n = 20, adenohypophysis n = 12)
- Inflamed RCC
- 23/31
- Not inflamed
- 8 cases
Preoperative features
- Pituitary dysfunction
- 70%
- Headache
- 65%
- Visual disturbance
- 26%
- Polyuria/polydipsia
- 7%
- Presented with features of apoplexy
- 6 patients
Pituitary dysfunction by inflammation overall
- Pituitary dysfunction not associated with inflammation overall (76% vs. 70% p = ns)
Pituitary dysfunction by adenohypophysitis
- Pituitary dysfunction not associated with adenohypophyseal inflammation (75 vs. 63% p = 0.69)
Radiological loss of posterior bright spot by histological inflammation
- Histological inflammation associated with loss of posterior bright spot (70% vs. 14% p = 0.024)
Original publication
Inflammation of adenohypophysis is commonly associated with headache in surgically managed Rathke’s cleft cysts. Pituitary. Published 27 December 2024. doi:10.
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