Inflammation-based Scores in Patients With Pheochromocytoma
Authors' conclusion
Inflammation-based scores in patients with pheochromocytoma showed pro-inflammatory changes that correlated with plasma metanephrine levels and are ameliorated by adrenalectomy and α-blockade.
Study context
- Population
- Patients with pheochromocytoma who underwent adrenalectomy (median age 53 years; 64.7% females) and matched controls
- Participants
- 68 / 68 / 53
- Comparison
- Pheochromocytoma vs nonfunctioning adrenocortical tumors vs essential hypertension
- Pheochromocytoman = 68
- Nonfunctioning adrenocortical tumorsn = 68reference
- Essential hypertensionn = 53reference
- Outcome
- Inflammation-based scores and correlation with plasma metanephrines
Methodological detailscontrols matched for age, sex and BMI
- Controls matched for age, sex and BMI
Main finding
As reported in the abstract
- Positive correlation of plasma metanephrines with NLR
- r = 0.4631
- Positive correlation of plasma metanephrines with PLR
- r = 0.3174
- Positive correlation of plasma metanephrines with SII
- r = 0.3709
- Negative correlation of plasma metanephrines with LMR
- r = 0.4368
- Negative correlation of plasma metanephrines with prognostic-nutrition index
- r = 0.3741
Observational data: associations, not effects.
Further findings
Change in inflammation-based scores after adrenalectomy (n = 26)
- Reduction in NLR
- P = 0.001
- Reduction in PLR
- P = 0.003
- Reduction in SII
- P = 0.004
- Increase in LMR
- P = 0.0002
Change in inflammation-based scores with preoperative α-blockade (n = 29) · before vs after α-blockade
- Reduction in NLR
- P = 0.007
- Reduction in SII
- P = 0.03
Original publication
Inflammation-based Scores in Patients With Pheochromocytoma. J Clin Endocrinol Metab. Published 24 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →