Cardiovascular Outcomes of KCNJ5 Mutated Aldosterone-Producing Adenoma: A Systematic Review
Authors' conclusion
This systematic review provided evidence of the significant association between KCNJ5 mutation and unfavorable cardiovascular outcomes in patients with primary aldosteronism. Further research is needed to improve the quality of evidence on this topic and elucidate the underlying mechanisms of the potential burden of KCNJ5 mutation.
Study context
- Population
- Patients with aldosterone-producing adenoma (APA); MEDLINE and Embase searched through August 202212 studies
- Comparison
- KCNJ5-mutated vs KCNJ5-non-mutated APA
- Outcome
- Cardiovascular and metabolic outcomes
Methodological detailsRisk of Bias In Non-randomized Studies of Interventions quality assessment, 573 titles/abstracts screened; full text read in 20
- Risk of Bias In Non-randomized Studies of Interventions quality assessment
- 573 titles/abstracts screened; full text read in 20
Pooled result
As reported in the abstract
- Cardiac function (3 studies): all reported an association between impaired cardiac functions and KCNJ5 mutation status
- Cure of hypertension after surgery (6 studies): all showed KCNJ5 mutation significantly associated with cure of hypertension
Further pooled results
- Studies at serious risk of bias
- 7
- Remaining studies at moderate risk of bias
Original publication
Cardiovascular Outcomes of KCNJ5 Mutated Aldosterone-Producing Adenoma: A Systematic Review. Endocr Pract. Published 22 April 2024. doi:10.
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