Histopathological evaluation based on CYP11B2 staining predicts outcomes in unilateral primary aldosteronism
Authors' conclusion
Classical histology was an independent variable associated with more severe PA, complete biochemical and hypertension remission in surgically treated patients with unilateral PA. Moreover, the distinction between APA and APN did not differentiate outcome.
Study context
- Population
- Consecutive patients with unilateral primary aldosteronism (PA) who underwent unilateral adrenalectomy; outcomes by PASO criteria
- Participants
- 131 patients
- Exposure
- Classical vs non-classical histology
- Classicaln = 101
- Non-classicaln = 30reference
- Outcome
- Complete biochemical success
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Complete hypertension remission
P < 0.001
Multivariable analysis: classical histology independently associated with complete success
- Complete biochemical success
- P < 0.001
- Complete clinical success
- P = 0.037
Patient characteristics, classical vs non-classical
- Classical histology patients younger
- P = 0.028
- Classical histology patients predominantly female
- P = 0.028
Aldosterone-producing adenoma (APA) vs aldosterone-producing nodule (APN)
- Clinical and biochemical outcomes similar between APA and APN
- Fewer clear cells and stronger CYP11B2 staining in APN
Original publication
Histopathological evaluation based on CYP11B2 staining predicts outcomes in unilateral primary aldosteronism. Eur J Endocrinol. Published 19 June 2025. doi:10.
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