Infertility and Pregnancy Rates in Female Thyroid Cancer Survivors: A Retrospective Cohort Study Using Health Care Administrative Data from Israel
Authors' conclusion
Pregnancy rates in TC survivors were comparable with controls. However, a higher infertility rate and a longer time to conceive were observed in the TC group compared with the control group. These findings were consistent in women who received single or repeated RAI treatments.
Study context
- Population
- Women diagnosed with thyroid cancer (TC) at age ≤40 years in 2000–2020, health management organization database, Israel; median age at diagnosis 31.6 years (IQR: 26.7–35.4)
- Participants
- 1,164 vs 5,030
- Exposure
- Female TC survivors vs healthy age-matched controls
- TCn = 1,164
- Controlsn = 5,030reference
- Outcome
- Infertility rate (documented diagnosis or purchase of fertility medications) and pregnancy rate
- Follow-up
- Median 10 years (IQR: 5.0-15.0)
Methodological detailshealth care administrative data, age-matched controls
- Health care administrative data
- Age-matched controls
Main finding
As reported in the abstract
Values
Pregnancy rate
- TC vs Controls: P = 0.008 — infertility higher with TC
- TC vs Controls: P = 0.625 — pregnancy rates comparable
Observational data: associations, not effects.
Further findings
Time to first pregnancy after diagnosis/referent date · longer with TC
P < 0.001
- Time to first pregnancy after diagnosis, within TC: repeated radioactive iodine (RAI) vs no repeated RAI · longer with repeated RAI
- P = 0.020
- Time to first pregnancy after diagnosis, within TC: repeated RAI vs no repeated RAI: repeated RAI: n = 611, 52.5% of TC group
Infertility and pregnancy rates, within TC: repeated RAI vs no repeated RAI
- Women with repeated RAI had comparable rates of infertility and pregnancy as those who did not
Original publication
Infertility and Pregnancy Rates in Female Thyroid Cancer Survivors: A Retrospective Cohort Study Using Health Care Administrative Data from Israel. Thyroid. Published 21 March 2023. doi:10.
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