Independent association of thigh muscle fat density with vascular events in Korean adults
Authors' conclusion
The current study suggests that a higher thigh muscle fat infiltration is associated with an increased risk of developing vascular events among Korean adults.
Study context
- Population
- Adults without baseline cardiovascular events, Korean Atherosclerosis Study-2; mean age 57.2 years, 47.7% women; mid-thigh muscle and fat area by computed tomography (CT) (low density muscle (LDM) 0–30 HU, normal density muscle (NDM) 31–100 HU, fat −250 to −50 HU)
- Participants
- 3,595 adults
- Exposure
- Individuals with vs without vascular events
- Outcome
- Vascular events
- Follow-up
- Median 11.8 (4.3-13.9) years
Main finding
As reported in the abstract
LDM area
- LDM/NDM ratio independently associated with vascular events after adjustment for cardiometabolic risk factors
- LDM/NDM ratio improved prognostic value for vascular events when added to conventional risk factors
- Vascular events vs No vascular events: P < 0.001
Observational data: associations, not effects.
Further findings
Incidence of vascular events by sex · median follow-up 11.8 years
- Vascular events in men
- 11.6%
- Vascular events in women
- 5.9%
Original publication
Independent association of thigh muscle fat density with vascular events in Korean adults. Cardiovasc Diabetol. Published 28 January 2024. doi:10.
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