Increased risk of hip and other major osteoporotic fractures within 18 months of lymphoma diagnosis—a national registry study of 36,864 Swedish lymphoma patients
Main finding · MOFResult — go to the resultIncidence rate ratio 1.14 95% CI 1.07–1.21Authors' conclusion
Compared with those of matched controls, the incidence of osteoporotic fractures among lymphoma patients within 18 months after lymphoma diagnosis was significantly greater. The risk was especially increased in the 51-60-year age group.
Study context
- Population
- Adult lymphoma patients diagnosed 2000–2018 in the Swedish Lymphoma Register and matched general-population controlsmatched cohort
- Participants
- 36,864 vs 368,082
- Exposure
- Lymphoma patients vs matched cohort from the general population
- Lymphoman = 36,864
- Matchedn = 368,082reference
- Outcome
- MOF, including hip fracture
- Follow-up
- Within 18 months of lymphoma diagnosis
Methodological detailspopulation-based, national registry, matched cohort
- Population-based
- National registry
- Matched cohort
Main finding
MOF
Incidence rate ratio
1.14
95% CI 1.07–1.21
Lymphomavs Matched
IRR 1.14 (95% CI 1.07–1.21)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Hip fracture · within 18 months of lymphoma diagnosisHip fracture n = 594 | IRR 1.14 (95% CI 1.05–1.24) | |
| MOF and hip fracture, age 51-60 (subgroup) · within 18 months of lymphoma diagnosisLymphomavs Matched | IRR (MOF) 1.64 (95% CI 1.47–2.27) | |
| MOF and hip fracture, age 51-60 (subgroup) · within 18 months of lymphoma diagnosisLymphomavs Matched | IRR (hip fracture) 2.60 (95% CI 1.85–3.63) | |
| MOF and hip fracture, diffuse large B cell lymphoma (subgroup)Lymphomavs Matched | IRR (MOF) 1.27 (95% CI 1.14–1.42) | |
| MOF and hip fracture, diffuse large B cell lymphoma (subgroup)Lymphomavs Matched | IRR (hip fracture) 1.24 (95% CI 1.07–1.44) | |
| 0.20.5125Ratio (log scale) |
Major osteoporotic fracture (MOF) and hip fracture risk · 15 years postdiagnosis
- Risk among lymphoma patients nearly equivalent to that of the general population
Original publication
Increased risk of hip and other major osteoporotic fractures within 18 months of lymphoma diagnosis—a national registry study of 36,864 Swedish lymphoma patients. Osteoporos Int. Published 4 November 2025. doi:10.
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