Increased prospective cardiovascular disease risk in 127 517 Nordic women with polycystic ovary syndrome: a national cohort study
Main finding · CVD, combined meta-analysisResult — go to the resultAdjusted hazard ratio 1.32 95% CI 1.25–1.39Authors' conclusion
The risk of CVD was increased in women with PCOS across the 3 Nordic countries, also among women with BMI < 25 kg/m2.
Study context
- Population
- Nordic women with polycystic ovary syndrome (PCOS) and age-matched controls from national registers of Denmark, Finland and Sweden; median age at entry 28 years (Denmark) and 29 years (Finland and Sweden)3 national cohorts
- Participants
- 127,517 vs 587,810
- Exposure
- PCOS vs age-matched controls
- PCOSn = 127,517
- Controlsn = 587,810reference
- Outcome
- CVD
Methodological detailsnational, age-matched controls, Denmark, Finland and Sweden, combined meta-analysis
- National
- Age-matched controls
- Denmark, Finland and Sweden
- Combined meta-analysis
Main finding
CVD, combined meta-analysis
Adjusted hazard ratio
1.32
95% CI 1.25–1.39
PCOSvs Controls
adjusted HR 1.32 (95% CI 1.25–1.39)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| CVD, unadjusted, by countryPCOSvs ControlsDenmark | unadjusted HR 1.30 (95% CI 1.20–1.41) | |
| CVD, unadjusted, by countryPCOSvs ControlsFinland | unadjusted HR 1.45 (95% CI 1.31–1.60) | |
| CVD, unadjusted, by countryPCOSvs ControlsSweden | unadjusted HR 1.52 (95% CI 1.44–1.60) | |
| CVD in women with BMI < 25 kg/m² and no T2D | adjusted HR 1.40 (95% CI 1.26–1.55) | |
| 0.512Ratio (log scale) |
Cardiovascular disease (CVD), unadjusted, by country
- Models remained significant after adjusting for obesity and level of education
Original publication
Increased prospective cardiovascular disease risk in 127 517 Nordic women with polycystic ovary syndrome: a national cohort study. Eur J Endocrinol. Published 24 December 2025. doi:10.
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