Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic
Authors' conclusion
We identified an increase in new-onset pediatric GD diagnoses during the COVID-19 pandemic. In addition, youths had increased severity of symptoms and more frequently required beta-blockade treatment at diagnosis. Further study of the relationship between COVID-19 and autoimmune thyroid disease is needed.
Study context
- Population
- Patients aged 0 to 18 years with new graves disease (GD) diagnoses at a tertiary care pediatric hospital, January 1, 2018 to December 31, 20214-year period
- Participants
- 51 patients
- Exposure
- During COVID-19 pandemic vs 2 prior years
- Outcome
- Incidence and characteristics of new GD diagnoses
Methodological detailsretrospective chart review, single-centre
- Retrospective chart review
- Single-centre
Main finding
As reported in the abstract
Incidence of new-onset GD
- Pandemic vs Pre-pandemic: P = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Severity at initial evaluation and treatment at diagnosisPandemic vs Pre-pandemic · heart rates higher during pandemic | P = 0.03 |
| Severity at initial evaluation and treatment at diagnosisPandemic vs Pre-pandemic · systolic BP higher during pandemic | P = 0.005 |
| Severity at initial evaluation and treatment at diagnosisPandemic vs Pre-pandemic · diastolic BP higher during pandemic | P = 0.01 |
| Severity at initial evaluation and treatment at diagnosisPandemic vs Pre-pandemic · palpitations more frequent during pandemic | P = 0.03 |
| Severity at initial evaluation and treatment at diagnosisPandemic vs Pre-pandemic · tremors more frequent during pandemic | P = 0.04 |
| Severity at initial evaluation and treatment at diagnosisPandemic vs Pre-pandemic · beta-blockade at diagnosis more frequent during pandemic | P = 0.002 |
Severity at initial evaluation and treatment at diagnosis
- Percentage requiring thionamide treatment and thionamide doses similar over time
Original publication
Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic. Endocr Pract. Published 2 February 2023. doi:10.
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