Increased Glycemic Variability in Patients With Chronic Pancreatitis and Diabetes Compared to Type 2 Diabetes
Authors' conclusion
Patients with pancreatic diabetes have higher glycemic variability than individuals with type 2 diabetes despite comparable levels of HbA1c.
Study context
- Population
- Patients with chronic pancreatitis and insulin-treated secondary diabetes and individuals with insulin-treated T2D, matched on HbA1c, age and sex; blinded continuous glucose monitoring (CGM) worn for 20±2 days
- Participants
- 30 vs 30
- Exposure
- Chronic pancreatitis with insulin-treated secondary diabetes vs insulin-treated T2D
- Chronic pancreatitisn = 30
- T2Dn = 30reference
- Outcome
- Glycemic control and variability by CGM (coefficient of variation (CV), SD, mean amplitude of glycemic excursions (MAGE), continuous overall net glycemic action (CONGA) at 1 and 2-hour intervals; time in predefined glucose ranges)
- Follow-up
- 20±2 days
Methodological detailsmatched on HbA1c, age, and sex, blinded CGM
- Matched on HbA1c, age, and sex
- Blinded CGM
Main finding
As reported in the abstract
CGM glycemic variability (CV, SD, MAGE, CONGA1, CONGA2)
- Chronic pancreatitis vs T2D: P < 0.01
Observational data: associations, not effects.
Further findings
Time with glucose >250 mg/dL · more time with chronic pancreatitis
P = 0.008
Time in target range (70-180 mg/dL) · less time with chronic pancreatitis
P = 0.044
Time at 54-69 mg/dL · more time with chronic pancreatitis
P = 0.041
- Glycemia risk index for hyperglycemia · higher with chronic pancreatitis
- P = 0.033
Glycemia risk index for hyperglycemia
- Glycemia risk index for hyperglycemia higher in chronic pancreatitis
Original publication
Increased Glycemic Variability in Patients With Chronic Pancreatitis and Diabetes Compared to Type 2 Diabetes. J Diabetes Sci Technol. Published 18 July 2025. doi:10.
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