Increased frequency of microalbuminuria in patients with type 3 autoimmune polyglandular syndrome (APS) compared to isolated autoimmune type 1 diabetes mellitus: A real-life study
Authors' conclusion
We found that patients with APS3 showed positive microalbuminuria, earlier than T1DM. Patients with APS3 showed higher frequency of AIT age of onset in the 16-30 age-range and those treated with levothyroxine had better metabolic control, than untreated ones.
Study context
- Population
- Patients with T1D alone or with autoimmune polyglandular syndrome (APS3)retrospective review
- Participants
- 214 vs 276
- Exposure
- APS3 vs T1D alone
- APS3n = 214
- T1DMn = 276reference
- Outcome
- Differences in metabolic control and chronic microvascular complications
Methodological detailsreal-life study
- Real-life study
Main finding
As reported in the abstract
Metabolic control and microvascular complications
- Microalbuminuria significantly more frequent in APS3 vs T1DM
- APS3 vs T1DM: P = 0.006
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Duration of diabetes and age of diabetes onsetT1DM vs APS3 · longer duration of diabetes with T1DM | P = 0.001 |
| Duration of diabetes and age of diabetes onsetT1DM vs APS3 · lower age of diabetes onset with T1DM | P = 0.020 |
| Female genderMore frequent with APS3 | P = 0.001 |
| HbA1c in APS3 by LT4 treatmentLT4-treated APS3 vs Non-treated APS3 · significantly better HbA1c with LT4 | P = 0.001 |
Age of AIT onset in APS3
- APS3 showed higher AIT onset frequency in the 16-30 quartile age-range
Original publication
Increased frequency of microalbuminuria in patients with type 3 autoimmune polyglandular syndrome (APS) compared to isolated autoimmune type 1 diabetes mellitus: A real-life study. Diabetes Res Clin Pract. Published 15 June 2024. doi:10.
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