Increased ferritin levels are associated with incident diabetes after kidney transplantation: A prospective cohort study
Authors' conclusion
Increased levels of ferritin are independently associated with a higher risk of post-transplant diabetes in kidney transplant recipients. Especially, kidney transplant recipients with ferritin levels > 500 µg/l, seem susceptible to the development of post-transplant diabetes over time.
Study context
- Population
- Stable adult kidney transplant recipients >1 year after transplantation, TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study, University Medical Center Groningen, the Netherlands; age 50 ± 12 years, 44 % women, median 6.1 [3.0–12.1] years after transplantation
- Participants
- 443 recipients
- Exposure
- Ferritin and hepcidin levels and incident post-transplant diabetes
- Ferritin >500 µg/ln = 40
- Outcome
- Incident post-transplant diabetes
- Follow-up
- Median 9.6 [6.3 - 10.2] years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Incident post-transplant diabetes, ferritin per 50 µg/l
Ferritin, HR per 50 µg/l
1.08
adjusted for potential confounders; 95 % CI 1.02–1.14
Developed post-transplant diabetes
65
15 %
Observational data: associations, not effects.
Further findings
| Outcome | HR (95 % CI) | |
|---|---|---|
| Incident post-transplant diabetes by ferritin cut-off | 2.81 (1.04–7.55) | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Increased ferritin levels are associated with incident diabetes after kidney transplantation: A prospective cohort study. Diabetes Metab. Published 15 February 2025. doi:10.
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