Increased Bone Material Strength Index Is Positively Associated With the Risk of Incident Osteoporotic Fractures in Older Swedish Women
Authors' conclusion
In conclusion, unexpectedly increasing BMSi was associated with greater fracture risk.
Study context
- Population
- Older Swedish women aged 75 to 80 years who underwent bone microindentation (OsteoProbe)
- Participants
- 647 women
- Exposure
- Higher vs lower bone material strength index (BMSi)
- Outcome
- Incident osteoporotic fracture
- Follow-up
- Median 6.0 years
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Incident fractures by BMSi (per SD increase)
Major osteoporotic fractures (MOF) events
121
Any fracture events
151
MOF, HR per SD BMSi
1.29
95% CI 1.07–1.56
Any fracture, HR per SD BMSi
1.29
95% CI 1.09–1.53
Observational data: associations, not effects.
Further findings
Mortality by BMSi (per SD) · median follow-up 6.0 years
- Deaths
- 50
- HR per SD BMSi
- 1.44 (95% CI 1.07-1.93)
BMSi association with age, BMI and bone mineral density (BMD)
- Age
- r = −0.13, p < 0.001
- BMI
- r = −0.21, p < 0.001
- Lumbar spine BMD (after adjustments)
- β = 0.09, p = 0.02
- Total hip BMD (after adjustments)
- β = 0.08, p = 0.05
- Weak associations
Prevalent fractures (self-reported and/or vertebral fracture assessment (VFA) identified)
- Women with prevalent fractures
- 332
- No significant association between BMSi and prevalent fractures
Original publication
Increased Bone Material Strength Index Is Positively Associated With the Risk of Incident Osteoporotic Fractures in Older Swedish Women. J Bone Miner Res. Published 23 April 2023. doi:10.
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