Incidence of diabetes-related foot disease: results from 2 prospective cohort studies and meta-analysis
Authors' conclusion
In conclusion, incidence for DFD exceeds 10 per 1,000 person-year among patients with diabetes, and peripheral neuropathy and foot ulcer are major contributors to incident DFD.
Study context
- Population
- Patients with diabetes free of diabetes-related foot disease (DFD), UK Biobank and Chongqing Diabetes Registry; DFD per International Working Group on the Diabetic Foot 2023 criteria2 cohorts + 64 cohorts
- Comparison
- UK Biobank vs Chongqing Diabetes Registry (CDR)
- Outcome
- Incidence of overall and individual components of DFD
Methodological details2 prospective cohorts, systematic review, meta-analysis of 64 cohorts
- 2 prospective cohorts
- Systematic review
- Meta-analysis of 64 cohorts
Pooled result
As reported in the abstract
Incidence of DFD
Further pooled results
Pooled incidence of DFD components (meta-analysis)
- Peripheral neuropathy
- 19.84 (95% CI 16.58-23.10)
- Foot ulcer
- 7.32 (CI 6.17-8.47)
- Lower-extremity amputation
- 2.56 (CI 2.20-2.93)
- Lower-extremity arterial disease
- 2.56 (CI 1.08-4.04)
- Gangrene
- 0.81 (CI 0.00-1.74)
- Heterogeneity across studies
- I2 > 99 %
Original publication
Incidence of diabetes-related foot disease: results from 2 prospective cohort studies and meta-analysis. Diabetes Res Clin Pract. Published 20 March 2026. doi:10.
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