Incidence of and Risk Factors for Neonatal Hypothyroidism Among Women with Graves' Disease Treated with Antithyroid Drugs Until Delivery
Authors' conclusion
Maternal fT4 and TRAb levels were higher in the neonatal hypothyroid group, which suggested prolonged GD activity.
Study context
- Population
- Pregnant women with Graves' disease (GD) treated with an antithyroid drug (ATD) until delivery
- Participants
- 305 women
- Exposure
- MMI vs PTU until delivery in pregnant women with GD
- MMIn = 63
- PTUn = 242
- Outcome
- Incidence of neonatal hypothyroidism among newborns of mothers with GD treated with ATD until delivery
- Follow-up
- At delivery
Main finding
As reported in the abstract
Neonatal hypothyroidism
Observational data: associations, not effects.
Secondary outcomes
Cutoff third-trimester ATD daily dose for neonatal hypothyroidism
mg/day
- Cutoff MMI dose
- 10
- Cutoff PTU dose
- 150
- Daily ATD dose in third trimester was the strongest predictor of neonatal hypothyroidism at delivery
Cutoff ATD dose when maternal third-trimester TRAb >3× upper limit of normal
mg/day
- Cutoff MMI dose
- 20
- Cutoff PTU dose
- 150
Safety
Neonatal goiter and levothyroxine need
- Neonatal goiter, PTU
- 1 neonate
- Required levothyroxine treatment, PTU
- 2 infants
Original publication
Incidence of and Risk Factors for Neonatal Hypothyroidism Among Women with Graves' Disease Treated with Antithyroid Drugs Until Delivery. Thyroid. Published 21 February 2023. doi:10.
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