Incidence and risks of coronary heart disease and heart failure in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry
Authors' conclusion
The incidence of heart disease was low and circulating adiponectin and sarcopenia may predict the development of heart disease in Japanese patients with type 2 diabetes.
Study context
- Population
- Japanese outpatients with T2D registered at multicenter diabetes clinics of a prefecture, 2008–2010 (mean age 65 years, male 57%, previous coronary heart disease (CHD) 14%)follow-up rate 98%
- Participants
- 4,874 outpatients
- Outcome
- Incidence of CHD and HF requiring hospitalization
- Follow-up
- Median 5.3 years
Methodological detailsmulticenter, registry
- Multicenter
- Registry
Main finding
As reported in the abstract
Incidence rates per 1,000 person-years
- CHD
- 12.3
- Silent myocardial ischemia
- 5.8
- Angina pectoris
- 4.3
- MI
- 2.1
- Hospitalized heart failure (HF)
- 3.1
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Risk factors for new-onset CHD (multivariable adjusted Cox)Highest quartile serum adiponectinvs Lowest quartile serum adiponectin | 1.6 (1.0–2.6) | |
| Risk factors for HF (multivariable adjusted Cox)Highest quartile serum adiponectinvs Lowest quartile serum adiponectin | 2.4 (1.1–5.2) | |
| Risk factors for HF (multivariable adjusted Cox)Lowest quartile serum creatinine/cystatin C ratiovs Highest quartile serum creatinine/cystatin C ratio | 4.6 (1.9–11.1) | |
| 0.050.21520Hazard ratio (log scale) |
- Risk factors for HF (multivariable adjusted Cox): creatinine/cystatin C ratio is a surrogate marker for sarcopenia
Original publication
Incidence and risks of coronary heart disease and heart failure in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. Diabetes Res Clin Pract. Published 26 May 2023. doi:10.
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