In people with type 2 diabetes, sarcopenia is associated with the incidence of cardiovascular disease: A prospective cohort study from the UK Biobank
An erratum to this article was published (Diabetes Obes Metab, Jun 2024 ↗)
Main finding · CVDResult — go to the resultHazard ratio 1.89 95% CI 1.61–2.21Authors' conclusion
In people with type 2 diabetes, sarcopenia increased the risk of developing CVD, which might occur earlier than in those without sarcopenia. Therefore, sarcopenia screening and prevention in patients with type 2 diabetes may be useful to prevent the complications of CVD.
Study context
- Population
- White European UK Biobank participants with T2D, aged 40–70 years
- Participants
- 11,974 participants
- Exposure
- Sarcopenia vs non-sarcopenia
- Outcome
- CVD incidence
- Follow-up
- Median 10.7 years
Methodological detailsUK Biobank, Cox proportional hazard models adjusted for sociodemographic and lifestyle factors
- UK Biobank
- Cox proportional hazard models adjusted for sociodemographic and lifestyle factors
Main finding
CVD
Hazard ratio
1.89
95% CI 1.61–2.21
Sarcopeniavs Non-sarcopenia
HR 1.89 (95% CI 1.61–2.21)
As reported in the abstract
- Participants who developed cardiovascular disease (CVD)
- 1957
- Sarcopenia: CVD incidence rates equivalent to those without sarcopenia who were years older (rate advancement period)
- 14.5 years
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| HFAdjusted for all covariates | 2.59 (2.12–3.18) | |
| StrokeAdjusted for all covariates | 1.90 (1.38–2.63) | |
| MIAdjusted for all covariates | 1.56 (1.04–2.33) | |
| 0.20.5125Hazard ratio (log scale) |
- Heart failure (HF) — Participants who developed HF
- 742
- Stroke — Participants who had a stroke
- 373
- Myocardial infarction (MI) — Participants who had an MI
- 307
Rate advancement period for stroke, HF and MI
- Similar results were found for stroke, HF and MI
Original publication
In people with type 2 diabetes, sarcopenia is associated with the incidence of cardiovascular disease: A prospective cohort study from the UK Biobank. Diabetes Obes Metab. Published 26 October 2023. doi:10.
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