Impaired metabolic flexibility to fasting is associated with increased ad libitum energy intake in healthy adults
Authors' conclusion
Impaired metabolic flexibility to fasting, reflected by an inability to transition away from carbohydrate oxidation, is linked with increased energy intake.
Study context
- Population
- Healthy, weight-stable volunteers (30 male, 14 female; mean age 39.3 years; BMI 31.7 kg/m²)
- Participants
- 44 participants
- Comparison
- 24-h fasting vs energy balance
- Outcome
- Association of fasting-induced changes in 24-h RER and substrate oxidation with subsequent 24-h ad libitum energy intake
Methodological detailsrespiratory chamber, 24-h fasting vs energy balance
- Respiratory chamber
- 24-h fasting vs energy balance
Main finding
As reported in the abstract
Smaller decrease in fasting 24-h respiratory exchange ratio (RER) associated with greater energy intake after fasting
r = 0.31
p = 0.04
Smaller decrease in carbohydrate oxidation associated with greater energy intake after fasting
r = 0.40
p = 0.007
Change in lipid oxidation not associated with energy intake after fasting
r = −0.27
p = 0.07
Further findings
| Outcome | Change (%) (95% CI) | P value |
|---|---|---|
| 24-h RERDecreased with fasting | 9.4 (−10.4% to −8.5%) | P < 0.0001 |
Carbohydrate oxidation
- Change in carbohydrate oxidation with fasting (mean [SD], MJ/day)
- −2.6 [0.8]; p < 0.0001
Lipid oxidation
- Increase in lipid oxidation with fasting (mean [SD], MJ/day)
- 2.3 [0.9]; p < 0.0001
Original publication
Impaired metabolic flexibility to fasting is associated with increased ad libitum energy intake in healthy adults. Obesity (Silver Spring). Published 23 April 2024. doi:10.
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