Impact of remnant cholesterol on short-term and long-term prognosis in patients with prediabetes or diabetes undergoing coronary artery bypass grafting: a large-scale cohort study
Authors' conclusion
Remnant-C is associated with AKI and MACCEs in patients with diabetes or prediabetes undergoing CABG. The MACCE risk associated with remnant-C is independent of LDL-C and is more pronounced in insulin-treated patients.
Study context
- Population
- Adults with prediabetes or DM undergoing isolated coronary artery bypass grafting (CABG), consecutively enrolled 2013–2018
- Exposure
- High vs low remnant cholesterol
- Outcome
- Acute kidney injury (AKI) stage 2/3 (perioperative)
- Follow-up
- Perioperative
Methodological detailslongitudinal cohort, consecutively enrolled, multivariate adjustment
- Longitudinal cohort
- Consecutively enrolled
- Multivariate adjustment
Main finding
As reported in the abstract
Odds ratio (95% CI)
High remnant-Cvs Low remnant-C
1.404(1.080–1.824)
Per 1-SD increase in remnant-C16.6% higher risk
1.160(1.067–1.260)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MACCEs (long-term) · median follow-up 3.2 years6.6% higher risk | 1.066 (1.012–1.124) | |
| All-cause death · median follow-up 3.2 years7.1% higher risk | 1.071 (1.008–1.209) | |
| MI · median follow-up 3.2 years11.2% higher risk | 1.112 (1.011–1.222) | |
| 0.512Hazard ratio (log scale) |
- Major Adverse Cardiovascular and Cerebrovascular Events (MACCEs) (long-term) — Patients experiencing MACCEs
- 1,251 (9.3%)
MACCEs (long-term) · median follow-up 3.2 years
- Association consistent with remnant cholesterol (remnant-C) as categorical variable
- Association independent of LDL-C (LDL-C ≤ 2.6 or > 2.6 mmol/L)
MACCEs by subgroup: insulin-treated
- Remnant-C–associated MACCE risk more pronounced in insulin-treated patients
Original publication
Impact of remnant cholesterol on short-term and long-term prognosis in patients with prediabetes or diabetes undergoing coronary artery bypass grafting: a large-scale cohort study. Cardiovasc Diabetol. Published 8 January 2025. doi:10.
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