Gestational diabetes & diabetes in pregnancy
Impact of Real Time, Flash and Retrospective Continuous Glucose Monitoring on Feto‐Maternal Outcomes in Women With Gestational Diabetes and Pre‐Gestational Diabetes: A Systematic Review and Meta‐Analysis With Trial Sequential Analysis of Randomized Controlled Trials
Authors' conclusion
RT-CGM probably reduces NICU admission (moderate-certainty), but TSA indicates that current evidence is still information-size limited
Study context
- Population
- Pregnant women with gestational diabetes mellitus (GDM) or pregestational diabetesRandomized controlled trials (RCTs) (13 GDM, 4 pregestational)
- Participants
- 17 women
- Comparison
- Continuous glucose monitoring (CGM) vs self-monitoring of blood glucose (SMBG)
- Outcome
- NICU admission and large-for-gestational-age (LGA) infants
Methodological detailstrial sequential analysis, CGM modalities and diabetes subtypes analysed separately
- Trial sequential analysis
- CGM modalities and diabetes subtypes analysed separately
Pooled result
As reported in the abstract
Each group vs SMBGOdds ratio (95% CI)P value
Real-time CGMNICU admission, GDM; I 2 = 0%
0.55(0.34–0.90)
P = 0.02Retrospective CGMLGA, GDM; I 2 = 0%
0.46(0.22–0.98)
P = 0.048Further pooled results
Other feto-maternal outcomes (birthweight, macrosomia, Caesarean delivery, hypertensive disorders, neonatal hypoglycaemia, preterm birth)
- No significant difference between CGM and SMBG
Feto-maternal outcomes in pregestational diabetes
- No CGM modality conferred measurable benefit
Original publication
Impact of Real Time, Flash and Retrospective Continuous Glucose Monitoring on Feto‐Maternal Outcomes in Women With Gestational Diabetes and Pre‐Gestational Diabetes: A Systematic Review and Meta‐Analysis With Trial Sequential Analysis of Randomized Controlled Trials. Diabetes Obes Metab. Published 7 April 2026. doi:10. 1111/ dom. 70743
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