Impact of weight change on kidney transplantation outcomes: A systematic review and meta‐analysis
Authors' conclusion
Substantial and clinically relevant weight gain after kidney transplant was associated with a higher risk of graft failure. Within the timeframes of study observation, risks of all-cause mortality, cardiovascular events or acute rejection were not increased by weight gain in kidney transplant recipients.
Study context
- Population
- Adult kidney transplant recipients (≥18 years); studies published up to 8 August 2024 (PubMed, Scopus)11 studies
- Comparison
- Post-transplant weight gain vs no such weight change
- Outcome
- All-cause mortality, graft failure, CV events, acute rejection
Pooled result
As reported in the abstract
Weight gain vs ControlHazard ratio (95% CI)P value
All-cause mortality; I2 = 28%
1.21(0.69–2.10)
P = 0.51CV events; I2 = 32%
0.93(0.43–2.01)
P = 0.85Acute rejection; I2 = 9%
1.13(0.76–1.68)
P = 0.55Graft failure; I2 = 0%
1.58(1.22–2.05)
P < 0.001Original publication
Impact of weight change on kidney transplantation outcomes: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 18 December 2024. doi:10.
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