Impact of the COVID-19 Pandemic on Children and Adolescents with New-Onset Type 1 Diabetes
Pooled result · T1D incidence rateResult — go to the resultRelative risk 1.200 95% CI 1.125–1.281Authors' conclusion
There is considerable evidence that there is an increase in type 1 diabetes in children during the COVID-19 pandemic. Many studies suggesting a direct effect of SARS-CoV-2 have methodological weaknesses. As no evidence of an increase in presymptomatic cases with isolated islet autoimmunity was found, this could also suggest an accelerated transition from presymptomatic patients to clinically overt type 1 diabetes. Furthermore, there was a marked exacerbation of the preexisting increase in the prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes during the pandemic. Both the increased incidence of paediatric type 1 diabetes and the higher prevalence of diabetic ketoacidosis at diagnosis led to a massive rise in the number of children with diabetic ketoacidosis during the pandemic.
Study context
- Population
- Children and adolescents with new-onset T1D; studies identified on PubMed
- Comparison
- COVID-19 pandemic period vs prepandemic period
- Outcome
- Relative risk of new-onset T1D
Methodological detailsrandom-effects meta-analysis, Poisson regression
- Random-effects meta-analysis
- Poisson regression
Pooled result
T1D incidence rate
Relative risk
1.200
95% CI 1.125–1.281
As reported in the abstract
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Risk of new-onset T1D after SARS-CoV-2 infectionAfter SARS-CoV-2 infection; risk increased by 62% | 1.622 (1.347–1.953) | |
| 0.512Relative risk (log scale) |
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →