Impact of Stroke History on the Risk of Recurrent Hip Fracture or Major Osteoporotic Fractures among Patients with Incident Hip Fracture: A Nationwide Cohort Study
Authors' conclusion
In conclusion, stroke history was associated with slightly higher risk of recurrent fracture among patients with first-time hip fracture in the overall analysis, although the CI included a null result. The association was modified by baseline mobility: Patients with stroke history and good mobility had a markedly higher risk, whereas patients with stroke and poor mobility did not.
Study context
- Population
- Patients with incident (first-time) hip fracture, Danish Multidisciplinary Hip Fracture Registry 2011–2018
- Participants
- 48,230 patients
- Exposure
- Prefracture stroke history vs no stroke history
- Outcome
- Cumulative incidence (competing risk of death) of recurrent hip fracture
- Follow-up
- 1 year
Methodological detailsregistry-based, Danish Multidisciplinary Hip Fracture Registry, 2011-2018
- Registry-based
- Danish Multidisciplinary Hip Fracture Registry, 2011-2018
Main finding
As reported in the abstract
Recurrent hip fracture, cumulative incidence
Observational data: associations, not effects.
Further findings
| Outcome | Stroke history | No stroke history | Adjusted HR (95% CI) | |
|---|---|---|---|---|
| Recurrent hip fracture, good mobility (Cumulated Ambulation Score ≥ 5) · 1 yearCumulative incidence (competing risk of death) | 5.8% (CI 4.3–7.5) | 3.7% (CI 3.4–4.0) | 1.55 (1.15–2.10) | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | Stroke history | No stroke history |
|---|---|---|
| Recurrent hip fracture, poor mobility (Cumulated Ambulation Score < 5) · 1 yearCumulative incidence (competing risk of death) | 4.4% (CI 3.6–5.5) | 5.0% (CI 4.7–5.3) |
- Recurrent hip fracture, poor mobility (Cumulated Ambulation Score < 5) — No association observed among patients with poor mobility; adjusted HR
- 0.88 (0.70-1.10) (95% CI)
Recurrent fracture at 2 years and major osteoporotic fractures
- Associations attenuated after 2 years of follow-up and for major osteoporotic fractures
Original publication
Impact of Stroke History on the Risk of Recurrent Hip Fracture or Major Osteoporotic Fractures among Patients with Incident Hip Fracture: A Nationwide Cohort Study. J Bone Miner Res. Published 19 December 2022. doi:10.
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