Impact of preoperative body mass index on postoperative outcomes in infective endocarditis: a multicenter analysis of 4801 consecutive patients
Authors' conclusion
IE patients with obesity present with comorbidities, higher 30-day mortality and lower 1-year survival rates, possibly linked to more frequent staphylococcal infections and comorbidities. This emphasises the need for early risk stratification, enhanced infection prevention and improved perioperative care in patients with obesity.
Study context
- Population
- Patients undergoing cardiac surgery for infective endocarditis, CAMPAIGN registry, Germany; mean age 65.0 [54.0–73.0] years116 excluded
- Participants
- 4,801 patients
- Exposure
- Preoperative body mass index (BMI) categories: underweight vs normal-weight vs overweight vs obesity
- Underweightn = 133
- Normal-weightn = 1,884reference
- Overweightn = 1,797
- Obesityn = 987
- Outcome
- 30-day and 1-year mortality
- Follow-up
- 30 days and 1 year
Methodological detailsmulticentre, registry-based (CAMPAIGN)
- Multicentre
- Registry-based (CAMPAIGN)
Main finding
As reported in the abstract
Obesity: 30-day mortality, worst of all groups
14.1%
Obesity: 1-year mortality, worst of all groups
19.6%
Observational data: associations, not effects.
Further findings
Comorbidities in Obesity · baseline
- Hypertension (p < 0.001)
- 63.0%
- DM (p < 0.001)
- 45.7%
- Coronary artery disease (p < 0.001)
- 29.5%
- Previous cardiac surgery (p < 0.012)
- 32.2%
- Dialysis-dependent CKD (p < 0.001)
- 11.6%
Causative organism
- Staphylococcal endocarditis in Obesity, highest prevalence (p < 0.001)
- 33.4%
- Streptococcal infection in Underweight, more frequent (p < 0.001)
- 22.0%
Original publication
Impact of preoperative body mass index on postoperative outcomes in infective endocarditis: a multicenter analysis of 4801 consecutive patients. Int J Obes (Lond). Published 13 September 2025. doi:10.
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