Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities
Authors' conclusion
Our findings reveal new mechanisms that uncouple obesity from cardiometabolic comorbidities
Study context
- Population
- UK Biobank participants; obesity in relation to cardiometabolic healthUK Biobank
- Participants
- 452,768 participants
- Outcome
- Uncoupling variants (adiposity-increasing alleles with lower cardiometabolic risk)
Methodological detailsmulti-trait genome-wide association analysis, individual-level data
- Multi-trait genome-wide association analysis
- Individual-level data
Main finding
As reported in the abstract
Variants where adiposity-increasing alleles were associated with lower cardiometabolic risk
266
Genomic loci
205
Further findings
Genetic subtypes of obesity
- Genetic subtypes formed by the 266 variants, each with distinct risk profiles and pathway signatures
- 8
Proteomic analyses
- Signatures separating adiposity- and health-driven effects
Original publication
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities. Nat Med. Published 12 September 2025. doi:10.
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