Impact of nasal septal deviation on surgical outcomes in endoscopic transsphenoidal surgery: a population-based study
Authors' conclusion
These findings indicate that patients with NSD undertaking ETA for PAs had higher risks of postoperative complications, including postoperative CSF leakage, DI, desmopressin use, hypopituitarism, and steroid use.
Study context
- Population
- Patients undergoing endoscopic transsphenoidal surgery for pituitary adenomas (PA); mean age 53.1 ± 15.8 (nasal septal deviation (NSD)) and 53.0 ± 16.0 years (non-NSD)initial cohort
- Participants
- 9,896 patients
- Exposure
- NSD vs non-NSD in ETA for PA
- NSDn = 2,002
- non-NSDn = 2,002reference
- Outcome
- Perioperative complications and postoperative endocrinological functions
Methodological detailspropensity-score matched, TriNetX database
- Propensity-score matched
- TriNetX database
Main finding
As reported in the abstract
Each group vs non-NSDEstimate (95% CI)P value
NSD
OR, postoperative CSF leakage 2.04(1.63–2.54)
P < 0.001NSD
OR, postoperative diabetes insipidus 1.36(1.18–1.57)
P < 0.001NSD
OR, desmopressin use 1.26(1.06–1.51)
P = 0.009NSD
OR, hypopituitarism 1.63(1.40–1.89)
P < 0.001NSD
OR, steroid use 1.43(1.25–1.62)
P < 0.001Observational data: associations, not effects.
Further findings
- Sensitivity analyses confirmed consistent results across different matching models
Original publication
Impact of nasal septal deviation on surgical outcomes in endoscopic transsphenoidal surgery: a population-based study. Pituitary. Published 17 May 2025. doi:10.
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