Impact of maternal prepregnancy body mass index on neonatal outcomes following extremely preterm birth
Authors' conclusion
No associations were seen between maternal BMI and outcomes for EP babies.
Study context
- Population
- Singleton births at 22 to 26 weeks' gestational age with a live fetus at maternal hospital admission; EXPRESS (Sweden, 2004–2007), EPICure 2 (UK, 2006), EPIPAGE 2 (France, 2011)3 national extremely preterm (EP) cohorts
- Participants
- 1,396 / 140 / 719 / 556 / 445
- Exposure
- Maternal prepregnancy BMI categories vs reference BMI
- Referencen = 1,396reference
- Underweightn = 140
- Overweightn = 719
- Obesityn = 556
- Missing BMIn = 445
- Outcome
- Survival without severe neonatal morbidity to hospital discharge
- Follow-up
- Hospital discharge
Methodological detailsprospective, cross-country design, three national EP birth cohorts (EXPRESS, EPICure 2, EPIPAGE 2)
- Prospective
- Cross-country design
- Three national EP birth cohorts (EXPRESS, EPICure 2, EPIPAGE 2)
Main finding
As reported in the abstract
Survival without major neonatal morbidity to hospital discharge
Each group vs referenceOR for survival without major neonatal morbidity (95% CI)
Underweight
1.31(0.82–2.08)
Overweight
1.00(0.77–1.29)
Obesity
0.94(0.70–1.25)
Observational data: associations, not effects.
Original publication
Impact of maternal prepregnancy body mass index on neonatal outcomes following extremely preterm birth. Obesity (Silver Spring). Published 6 February 2025. doi:10.
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