Impact of COVID-19 Lockdown on Metabolic/Inflammatory Profile in Adolescents: Cellular Studies and Predictive Biomarkers
Authors' conclusion
Our findings highlight that the COVID-19 lockdown, forcing sedentary behavior, had a negative impact on adolescents' metabolic and inflammatory profile which may result in long-term poor health outcomes.
Study context
- Population
- Healthy adolescents from southern Italy
- Participants
- 77 adolescents
- Exposure
- Postlockdown vs prelockdown COVID-19
- Outcome
- Anthropometry, body composition, MD adherence and serum metabolic/inflammatory profile
Methodological detailsbefore-and-after (prelockdown vs postlockdown), cellular studies in HepG2 and HuH-7 hepatic cells
- Before-and-after (prelockdown vs postlockdown)
- Cellular studies in HepG2 and HuH-7 hepatic cells
Main finding
As reported in the abstract
- No significant differences in anthropometric and body composition parameters or MD adherence score, postlockdown vs prelockdown
- Increased fasting glucose, TG, total cholesterol and low-density lipoprotein (LDL), and reduced high-density lipoprotein (HDL) postlockdown vs prelockdown (metabolic profile within normal range)
- Elevated tumor necrosis factor (TNF)-α, interleukin-1β and ferritin postlockdown vs prelockdown
Observational data: associations, not effects.
Further findings
Effects of pooled serum on HepG2 and HuH-7 hepatic cells
- Enhanced lipid accumulation, altered mitochondrial functions and increased reactive oxygen species production with postlockdown vs prelockdown serum
ROC curve analysis of predictive serum markers
- Total cholesterol, LDL, HDL, TNF-α and ferritin identified as predictive serum markers for metabolic and inflammatory profiling after lockdown
Original publication
Impact of COVID-19 Lockdown on Metabolic/Inflammatory Profile in Adolescents: Cellular Studies and Predictive Biomarkers. J Clin Endocrinol Metab. Published 11 October 2023. doi:10.
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