Plasma Sphingolipid Profile of Healthy Black and White Adults Differs Based on Their Parental History of Type 2 Diabetes
Authors' conclusion
Elevated levels of sphingomyelin, the major sphingolipids of plasma, and oleic acid-containing sphingolipids in healthy FH+ subjects compared with healthy FH- subjects may reflect heritable elements linking sphingolipids and the development of T2D.
Study context
- Population
- Healthy Black and White adults with or without family history of T2D; CASPID study
- Participants
- 140 vs 100
- Exposure
- Adults with vs without family history of T2D
- FH+n = 140
- FH-n = 100reference
- Outcome
- Fasting plasma levels of 58 sphingolipid species (ceramides, monohexosylceramides, sphingomyelins, long-chain sphingoid base-containing species), by liquid chromatography/mass spectrometry
Main finding
As reported in the abstract
Plasma sphingolipid composition (share of total sphingolipids)
Sphingomyelin
Ceramides
Monohexosylceramides
Observational data: associations, not effects.
Original publication
Plasma Sphingolipid Profile of Healthy Black and White Adults Differs Based on Their Parental History of Type 2 Diabetes. J Clin Endocrinol Metab. Published 7 October 2023. doi:10.
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