Impact of acute glycemic variability on short-term outcomes in patients with ST-segment elevation myocardial infarction: a multicenter population-based study
Authors' conclusion
Our study findings indicate that a high GV during hospitalization was significantly associated with an increased risk of 30-day all-cause mortality and MACE in Chinese patients with STEMI. Moreover, acute GV emerged as an independent predictor of increased MACEs risk, regardless of DM status.
Study context
- Population
- Chinese patients with acute STEMI, 274 centers in China7,510 enrolled
- Participants
- 7,136 patients
- Exposure
- Glycemic variability (GV) tertiles
- Outcome
- All-cause death
- Follow-up
- 30 days
Methodological detailspopulation-based, consecutive patients, 274 centers in China
- Population-based
- Consecutive patients
- 274 centers in China
Main finding
As reported in the abstract
30-day all-cause mortality
P = 0.004
- GV as continuous variable, all-cause mortality: HR
- 1.679 (1.005-2.804) (95% CI)
Observational data: associations, not effects.
Secondary outcomes
MACE · 30 days — between GV3 and GV1 · across GV tertiles
P < 0.001
- MACE — GV as continuous variable, MACE: HR
- 2.064 (1.386-3.074) (95% CI)
MACE · 30 days
- GV3 predicted increased MACE risk irrespective of diabetes mellitus (DM)
Original publication
Impact of acute glycemic variability on short-term outcomes in patients with ST-segment elevation myocardial infarction: a multicenter population-based study. Cardiovasc Diabetol. Published 7 May 2024. doi:10.
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