Impact of a 12‐week personalized dietary intervention on vascular function and cardiovascular risk factors
Authors' conclusion
A 12-week diet improves metabolic and cardiovascular outcomes, but not vascular function in insulin-resistant adults with overweight or obesity. Whilst the LFHP diet resulted in greater improvements in cardiometabolic risk markers than the HMUFA diet, we found no significant differences between the PhenoDiet groups.
Study context
- Population
- Insulin-resistant adults with overweight or obesity, muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotype; 54 women, 61 ± 7 years, BMI 27.6 [26.4;30.0] kg/m²101 finished
- Participants
- 119 adults
- Comparison
- PhenoDiet A vs PhenoDiet B; LFHP vs HMUFA diet
- Primary endpoint
- Vascular function
Methodological detailssub-analysis, Drop-out n = 18
- Sub-analysis
- Drop-out n = 18
Primary result
As reported in the abstract
Vascular function (carotid artery reactivity) · 12 weeks
- Overall, vascular function not affected by diet
- p = 0.485
Further findings
| Outcome | P value |
|---|---|
| Matsuda index and total cholesterol, PhenoDiet B vs A · 12 weeksPhenoDiet B vs PhenoDiet A · Matsuda index tended to increase more with B | P = 0.078 |
| Matsuda index and total cholesterol, PhenoDiet B vs A · 12 weeksPhenoDiet B vs PhenoDiet A · total cholesterol tended to decrease more with B | P = 0.052 |
| Cholesterol, DBP and insulin resistance, LFHP vs HMUFA · 12 weeksMore pronounced improvements with LFHP | all p < 0.05 |
BP, total cholesterol, HDL-C, Framingham risk score (overall) · 12 weeks
- Significantly decreased after diet
- all p < 0.05
Insulin resistance and disposition index (overall) · 12 weeks
- Insulin resistance significantly improved
- P ≤ 0.001
- Disposition index not improved
- P = 0.362
Original publication
Impact of a 12‐week personalized dietary intervention on vascular function and cardiovascular risk factors. Diabetes Obes Metab. Published 27 February 2025. doi:10.
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