The impact of metabolic heterogeneity of obesity and transitions on cardiovascular disease incidence in Chinese middle‐aged and elderly population: A nationwide prospective cohort study
Authors' conclusion
The study highlights the importance of maintaining and promoting metabolic health, particularly in overweight/obese individuals, to reduce CVD risk. Metabolic health status plays a more crucial role than obesity status in predicting CVD incidence.
Study context
- Population
- Chinese residents aged ≥45 years, China Health and Retirement Longitudinal Study (CHARLS); baseline 2011–2012, follow-up to 2020
- Participants
- 7,721 residents
- Exposure
- BMI-metabolic phenotypes vs metabolically healthy normal weight (MHNW)
- Outcome
- CVD incidence
Methodological detailsnationwide, longitudinal
- Nationwide
- Longitudinal
Main finding
As reported in the abstract
Incident CVD
Each group vs MHNWHazard ratio (95% CI)P value
MUOO
1.74(1.50–2.09)
P < 0.0001MUNW
1.35(1.13–1.66)
P < 0.001MHOO
1.29(1.08–1.56)
P = 0.002- Developed cardiovascular disease (CVD) during follow-up (overall)
- 1353 (17.5%)
Observational data: associations, not effects.
Further findings
Phenotype transitions over 4 years
- Deterioration of obesity and metabolic health status elevated CVD incidence; improvements reduced CVD risk
- Changes in metabolic health status conferred greater benefits in overweight/obese than normal-weight individuals
Original publication
The impact of metabolic heterogeneity of obesity and transitions on cardiovascular disease incidence in Chinese middle‐aged and elderly population: A nationwide prospective cohort study. Diabetes Obes Metab. Published 4 November 2024. doi:10.
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