The impact of insulin pump therapy compared to multiple daily injections on complications and mortality in type 1 diabetes: A real‐world retrospective cohort study
Main finding · All-cause mortalityResult — go to the resultRelative risk 0.716 95% CI 0.639–0.803Authors' conclusion
Insulin pump therapy was associated with lower all-cause mortality and risk of diabetic ketoacidosis, but an increased risk of diabetic retinopathy compared with MDI. This result should be interpreted with caution due to potential differences in retinal screening frequency and subsequent bias.
Study context
- Population
- Adults with T1D, TriNetX global network of anonymised medical records; 5-year follow-up between January 2018 and March 202595,122 identified
- Participants
- 17,124 vs 17,124
- Exposure
- Insulin pump therapy vs multiple daily injections (MDI)
- Pumpn = 17,124
- MDIn = 17,124reference
- Outcome
- All-cause mortality
Methodological detailsreal-world, propensity score matched, TriNetX platform
- Real-world
- Propensity score matched
- TriNetX platform
Main finding
As reported in the abstract
Relative risk
0.716
95% CI 0.639–0.803
P < 0.001
Pumpvs MDI
RR 0.716 (95% CI 0.639–0.803); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| DKA | 0.848 (0.786–0.915) | P < 0.001 | |
| 0.512Relative risk (log scale) |
| Outcome | Pump | MDI |
|---|---|---|
| Absolute reduction in HbA1c · five years | −5.3 mmol/mol | −4.5 mmol/mol |
| % | −0.5% | −0.4% |
Absolute reduction in HbA1c · five years
- Absolute reduction in HbA1c was comparable at five years
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Diabetic retinopathy | 1.331 (1.247–1.420) | P < 0.001 | |
| 0.512Relative risk (log scale) |
Original publication
The impact of insulin pump therapy compared to multiple daily injections on complications and mortality in type 1 diabetes: A real‐world retrospective cohort study. Diabetes Obes Metab. Published 19 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →