Effect of glycemic status on myocardial deformation and microvascular function in uncomplicated pediatric type 1 diabetes mellitus: cardiac magnetic resonance imaging
Authors' conclusion
Pediatric T1DM with higher HbA1c showed worse myocardial perfusion and subclinical diastolic dysfunction. Microvascular dysfunction was associated independently with cardiac dysfunction.
Study context
- Population
- Uncomplicated pediatric patients with T1D and controls undergoing 3.0 T cardiac MRI100 T1D, 35 controls
- Exposure
- T1D with HbA1c ≥7.0% vs HbA1c <7.0% vs controls
- Outcome
- Left ventricular (LV) myocardial perfusion and deformation
Methodological details3.0 T cardiac magnetic resonance (CMR), first-pass perfusion imaging at rest, multivariable linear regression
- 3.0 T CMR
- First-pass perfusion imaging at rest
- Multivariable linear regression
Main finding
As reported in the abstract
- Longitudinal peak diastolic strain rate (PDSR) deteriorated gradually from controls through HbA1c < 7.0% to HbA1c ≥ 7.0% (all p < 0.05)
- HbA1c ≥ 7.0% vs HbA1c < 7.0%: P = 0.007
- HbA1c ≥ 7.0% vs Controls: P < 0.001
- HbA1c ≥ 7.0% vs Controls: P = 0.025
- HbA1c ≥ 7.0% vs Controls: 0.016
- HbA1c < 7.0% vs Controls: P = 0.566
- HbA1c < 7.0% vs Controls: 0.379
Observational data: associations, not effects.
Further findings
Multivariable analysis: elevated HbA1c and perfusion/deformation
- Elevated HbA1c and reduced upslope, β (p < 0.001)
- - 2.53
- Elevated HbA1c and reduced longitudinal PDSR, β (p = 0.007)
- - 0.02
Multivariable analysis: perfusion indices and longitudinal PDSR
- Upslope, β (p = 0.016)
- 0.10
- Maximum signal intensity (MaxSI), β (p = 0.006)
- - 0.02
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of glycemic status on myocardial deformation and microvascular function in uncomplicated pediatric type 1 diabetes mellitus: cardiac magnetic resonance imaging. Cardiovasc Diabetol. Published 16 May 2025. doi:10.
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