Impact of cardiovascular autonomic neuropathy on cardiopulmonary, sympathoadrenal and metabolic responses to physical exercise in adults with type 1 diabetes
Authors' conclusion
In adults with type 1 diabetes, CAN was associated with exercise intolerance characterised by impairments in various cardiopulmonary, sympathoadrenal system and metabolic responses to GXT. These data support uncovering the presence of CAN when prescribing a personalised physical training plan.
Study context
- Population
- Adults with T1D with or without cardiovascular autonomic neuropathy undergoing a graded maximal exercise test
- Participants
- 24 vs 24
- Comparison
- T1D with cardiovascular autonomic neuropathy (CAN) vs without CAN
- CANn = 24
- NO CANn = 24reference
- Outcome
- V̇O2peak
- Follow-up
- GXT
Methodological detailsgraded maximal exercise test, matched controls, Independent t tests and two-factor ANOVAs; significance p≤0.05
- Graded maximal exercise test
- Matched controls
- Independent t tests and two-factor ANOVAs; significance p≤0.05
Main finding
As reported in the abstract
Further findings
Peak adrenaline · peak workload · lower with CAN
P = 0.002
Peak noradrenaline · peak workload · lower with CAN
P = 0.007
| Outcome | CAN | NO CAN | P value |
|---|---|---|---|
| Change in adrenaline, rest to peak · rest to peak workloadLower with CAN | +0.13 ± 0.12 ng/ml | +0.32 ± 0.24 ng/ml | P = 0.005 |
| Change in noradrenaline, rest to peak · rest to peak workloadLower with CAN | +1.33 ± 0.89 ng/ml | +2.33 ± 1.30 ng/ml | P = 0.005 |
Plasma glucose during exercise · throughout exercise
- PG similar between groups and unchanged from rest irrespective of CAN status
Original publication
Impact of cardiovascular autonomic neuropathy on cardiopulmonary, sympathoadrenal and metabolic responses to physical exercise in adults with type 1 diabetes. Diabetologia. Published 9 December 2025. doi:10.
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